Detaillierte Hinweise zur Methadontabletten zur Schmerzbehandlung
Detaillierte Hinweise zur Methadontabletten zur Schmerzbehandlung
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HIV drugs, such as ritonavir or indinavir. Taking these drugs with methadone may cause increased drowsiness and slowed breathing. Your doctor might adjust your dosage of methadone, depending on how severe your side effects are.
Infants born to mothers physically dependent on opioids may also Beryllium physically dependent and may exhibit respiratory difficulties and withdrawal symptoms (Teich PRECAUTIONS, Pregnancy, Labor and Delivery).
Clinical Pharmacology for Pregnancy – Pregnant women appear to have significantly lower trough plasma methadone concentrations, increased plasma methadone clearance, and shorter methadone half-life than after delivery.
Optimal methadone initiation and dose titration strategies for the treatment of pain have not been determined. Published equianalgesic conversion ratios between methadone and other opioids are imprecise, providing at best, only Individuenbestand averages that cannot be applied consistently to all patients. It should Beryllium noted that many commonly cited equianalgesia tables only present relative analgesic potencies of single opioid doses hinein non-tolerant patients, thus greatly underestimating methadone's analgesic potency, and its potential for adverse effects hinein repeated-dose settings.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Methadone treatment for analgesic therapy in patients with acute or chronic pain should only Beryllium initiated if the potential analgesic or palliative care benefit of treatment with methadone has been considered to outweigh the risk of QT prolongation that has been reported with high doses of methadone.
If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:
Do not take a higher dose of methadone hydrochloride tablets or take it more often than prescribed. This can lead to an overdose and possible death.
Methadone should be used with caution in elderly and debilitated patients; patients Weltgesundheitsorganisation are known to Beryllium sensitive to central nervous system depressants, such as those with cardiovascular, pulmonary, renal, or hepatic disease; and hinein patients with comorbid conditions or concomitant medications which may predispose to dysrhythmia.
Patients should Beryllium cautioned that methadone, like all opioids, may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving or operating machinery.
Antibiotics, such as clarithromycin and erythromycin. Taking these drugs with methadone may cause increased drowsiness and slowed breathing. Your doctor might adjust your dosage of methadone, depending on how severe your side effects are.
Infants born to mothers physically dependent on opioids may also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms (see PRECAUTIONS, Pregnancy, Labor and Delivery).
However, the risk is highest when you first start Methadontabletten ohne Rezept online taking the drug and after a dosage increase. Your risk may also Beryllium higher if you’Response older or already have breathing or lung problems.
These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation or dose titration.